Diabetes, Nitric Oxide, and Heat Shock Proteins
نویسندگان
چکیده
منابع مشابه
HDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
متن کاملHeat shock proteins and macrophage resistance to the toxic effects of nitric oxide.
Nitric oxide (NO) functions as a pathophysiological mediator in mammalian tissues. Activated macrophages produce NO as a non-specific immune response directed against invading bacteria or micro-organisms. The same macrophages that initiate the production of NO also can be toxically affected by NO. Incubation of RAW 264.7 macrophages with lipopolysaccharide (LPS) and/or interferon-gamma (INF-gam...
متن کاملHeat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs.
NO is a cytotoxic and immunomodulatory cytokine produced by macrophages and dendritic cells. We show that stimulation of murine and human macrophages with the heat shock proteins gp96 and hsp70 results in induction of inducible NO synthase and the production of NO. The release of NO by monocytes exposed to hsp60 has been documented previously. Immature, but not mature, dendritic cells respond i...
متن کاملHeat shock and the heat shock proteins.
As all biologists appreciate, there is constant interaction between life and the environment, and temperature plays a critical role. It establishes distribution limits, it affects rates of function as well as the survival of organisms. Notoriously sensitive to temperature is plant growth. Critical steps in plant life such as germination, flowering and breaking of dormancy can be manipulated by ...
متن کاملLoss of defense against stress: diabetes and heat shock proteins.
WE PROPOSE THAT DIABETES produces a vulnerable condition with impaired defenses against stress, resulting in widespread unprotected organ systems. More specifically, the ultimate natural history of diabetes and its complications is determined by the net effect of diabetes-induced inflammation, oxidation, and glycation, as well as an induced deficiency of heat shock factor-1 (HSF-1) that subsequ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes Care
سال: 2003
ISSN: 0149-5992,1935-5548
DOI: 10.2337/diacare.26.3.951